Transformed cell having ability to produce 2,5-pyridine dicarboxylic acid
AssigneeKao Corporation
InventorsKyoshiro Nonaka, Fumikazu Takahashi
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Abstract
Provided are a transformed cell having the ability to produce 2,5-pyridine dicarboxylic acids, and a method for producing 2,5-pyridine dicarboxylic acids using the same. The present invention provides a transformed cell having the ability to produce 2,5-pyridine dicarboxylic acids, the transformed cell being derived from a microbe having the ability to biosynthesize 4-aminobenzoic acids and having the enhanced expression of the following polypeptides (I) and (II): (I) a polypeptide having 4-aminobenzoic acid hydroxylation activity, and (II) a polypeptide having 4-amino-3-hydroxybenzoate 2,3-dioxygenase activity.
Claims17
A transformed cell comprising:
- (I) a foreign polynucleotide encoding a polypeptide having 4-aminobenzoic acid hydroxylation activity, and
- (II) a foreign polynucleotide encoding a polypeptide having 4-amino-3-hydroxybenzoate 2,3-dioxygenase activity;
- wherein the transformed cell biosynthesizes 4-aminobenzoic acids;
- wherein the transformed cell produces 2,5-pyridine dicarboxylic acids;
- and
- wherein the transformed cell is E. coli or a bacterium of the genus Corynebacterium.
Dependencies are inferred from the claim text.