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AssigneeThe Regents of the University of California
InventorsJennifer A. Doudna, Jillian F. Banfield, David Burstein, Lucas Benjamin Harrington, Steven C. Strutt
Estimating the term…
The present disclosure provides CasX proteins, nucleic acids encoding the CasX proteins, and modified host cells comprising the CasX proteins and/or nucleic acids encoding same. CasX proteins are useful in a variety of applications, which are provided. The present disclosure provides CasX guide RNAs that bind to and provide sequence specificity to the CasX proteins, nucleic acids encoding the CasX guide RNAs, and modified host cells comprising the CasX guide RNAs and/or nucleic acids encoding same. CasX guide RNAs are useful in a variety of applications, which are provided. The present disclosure provides archaeal Cas9 polypeptides and nucleic acids encoding same, as well as their associated archaeal Cas9 guide RNAs and nucleic acids encoding same.
A method of modulating transcription from a target DNA, modifying a target DNA, or modifying a protein associated with a target DNA, the method comprising contacting the target DNA with:
Dependencies are inferred from the claim text.