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US 12,637,678 B2Granted
Anti-fibrotic compositions comprising FENDRR or fragments or variants thereof and methods of production and use thereof
AssigneeThe Board of Regents for the Oklahoma Agricultural and Mechanical Colleges
InventorsLin Liu, Chaoqun Huang
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Abstract
Compositions containing long non-coding RNAs (lncRNA's) or fragments or variants thereof are disclosed. Also disclosed are compositions containing vectors that include or encode the lncRNA's or fragments/variants thereof. Further disclosed are methods of producing and using these compositions containing or encoding the lncRNA's.
Claims5
A method of treating or reducing the occurrence of idiopathic pulmonary fibrosis in a subject, comprising the step of:
- administering a composition to the subject, wherein the composition is selected from the group consisting of:
- (i) a composition comprising a Fetal-lethal noncoding developmental regulatory RNA (FENDRR) lncRNA and a pharmaceutically-acceptable carrier, wherein the FENDRR lncRNA is encoded by a sequence comprising at least one of SEQ ID NOS:
- 1-3 and 133-134;
- and
- (ii) a composition comprising a vector and a pharmaceutically-acceptable carrier, wherein the vector comprises a sequence encoding a Fetal-lethal noncoding developmental regulatory RNA (FENDRR) lncRNA, wherein the sequence comprises at least one of SEQ ID NOS:
- 1-3 and 133-134.
3 more elements
Dependencies are inferred from the claim text.