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US 12,637,667 B2Granted
FokI nuclease domain mutant
AssigneesEditForce, Inc., Kyushu University, National University Corporation
InventorsYusuke Yagi, Masaru Ohta, Takahiro Nakamura
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Abstract
It was found that four nuclease domain mutants have nuclease activity superior to that of a wild-type nuclease domain and are capable of enhancing genome editing efficiency in combination with various nucleic acid binding domains.
Claims8
A nuclease domain mutant of a FokI protein, comprising the amino acid sequence set forth in SEQ ID NO:
- 11, 12, 13, or 14.
Dependencies are inferred from the claim text.