In-line product monitoring in integrated continuous bio-manufacturing
AssigneeGenzyme Corporation
InventorsRobert Snow, Joseph P. Kutzko, Xuezhen Kang
Life of this patent
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Abstract
Methods for controlling a biological manufacturing system include directing a light beam to pass through a wall of a vessel containing a first fluid generated by the biological manufacturing system, measuring an angle of refraction of the light beam in the first fluid, the angle of refraction corresponding to an angle between a propagation direction of the light beam in the first fluid and a normal to an interface between the vessel wall and the first fluid, determining information about the first fluid based on the measured angle of refraction, and adjusting a parameter of the biological manufacturing system based on the information about the first fluid.
Claims12
A method for controlling a biological manufacturing system, the method comprising:
- directing a light beam to pass through a wall of a vessel or conduit containing a first fluid generated by the biological manufacturing system;
- measuring an angle of refraction of the light beam in the first fluid, the angle of refraction corresponding to an angle between a propagation direction of the light beam in the first fluid and a normal to an interface between the vessel or conduit wall and the first fluid;
- determining information about the first fluid based on the measured angle of refraction;
- and
- adjusting a parameter of the biological manufacturing system based on the information about the first fluid,
- wherein the parameter of the biological manufacturing system comprises a feed rate of a substance into a reactor of the system.
Dependencies are inferred from the claim text.