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US 12,637,649 B2Granted
Sampling system and sampling method
AssigneeTerumo Kabushiki Kaisha
InventorMasatsugu Igarashi
Life of this patent
Estimating the term…
Abstract
A sampling system includes a sensor (for example, a biosensor) that is provided in a sampling channel so as to be in contact with a sample and measures concentrations of predetermined components in the sample, an introduction path that introduces a cleaning liquid to an upstream side of the sensor of the sampling channel, and an air introduction path that is connected to the introduction path and is opened to the atmosphere. The air guided from the air introduction path flows into the sampling channel via the introduction path.
Claims19
A sampling system comprising:
- a sampling channel system configured to receive a liquid sample from a cell culture device;
- a biosensor disposed in the sampling channel system so as to be in fluid communication with the liquid sample and configured to measure concentrations of predetermined components in the liquid sample;
- an introduction path that is configured to introduce a cleaning liquid to the sampling channel system upstream of the biosensor, the cleaning liquid including a buffer solution or physiological saline;
- and
- an air path connected to the introduction path and opened to an atmosphere, wherein air guided from the air path flows into the sampling channel system through the introduction path.
2 more elements
A sampling method comprising:
- a sampling step including
- moving a liquid sample disposed in a sampling channel system of a sampling system and received from cell culture device, the sampling system including a biosensor disposed in the sampling channel system and in fluid contact with the sample, and
- measuring concentrations of predetermined components in the sample by the biosensor;
- a cleaning step including
- introducing a cleaning liquid from an introduction path of the sampling system to sampling channel system upstream of the biosensor, the cleaning liquid including a buffer solution or physiological saline, and
- moving the cleaning liquid through the sampling channel system;
- and
- an air introduction step including
- introducing air from the introduction path to the sampling channel system,
- wherein the sampling step is performed two or more times, and a second and subsequent sampling steps are performed after the air introduction step.
7 more elements
A sampling system comprising:
- a sampling channel system configured to receive a liquid sample from a cell culture device and including
- a sensor for communicating with the liquid sample and configured to measure concentrations of components in the liquid sample;
- and
- an introduction path configured to introduce a cleaning liquid to the sampling channel system upstream of the sensor and also configured to introduce a standard solution selected for calibrating the sensor upstream of the sensor, the introduction path including
- an air path that includes an air port portion opened to the atmosphere and having a sterile filter disposed therewithin the that is configured to maintain a sterile state of the sampling system.
2 more elements
Dependencies are inferred from the claim text.