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US 12,637,645 B2Granted
Deformability of a cell responsive to a pressure wave
AssigneeHewlett-Packard Development Company, L.P.
InventorsFausto D'Apuzzo, Viktor Shkolnikov, Alexander Govyadinov
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Abstract
An example method for measuring deformability of a cell responsive to a pressure wave, consistent with the present disclosure, includes moving a cell of a sample into a cell probing chamber of a microfluidic device. While the cell is in the cell probing chamber, the method includes generating a pressure wave within the cell probing chamber by actuating a fluidic pump. The method further includes determining a deformability of the cell responsive to the pressure wave, using an imaging array synchronized with the actuation of the fluidic pump.
Claims7
A method, comprising:
- moving a cell of a sample into a cell probing chamber of a microfluidic device;
- while the cell is in the cell probing chamber, generating a pressure wave within the cell probing chamber by actuating a fluidic pump;
- acquiring, using an imaging array, a plurality of images of the cell, wherein the imaging array is synchronized with each actuation of the fluidic pump such that the plurality of images are acquired before, during, and after each pressure wave is applied;
- and
- determining a deformability of the cell responsive to the pressure wave, based on the images acquired in synchronization with the actuation of the fluidic pump.
2 more elements
Dependencies are inferred from the claim text.