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US 12,637,510 B2Granted
Oncolytic virus compositions and methods for the treatment of cancer
AssigneeCity of Hope
InventorsJianhua Yu, Michael A. Caligiuri
Life of this patent
Estimating the term…
Abstract
Provided herein, inter alia, are compositions and methods including recombinant oncolytic viruses expressing CD47 antibody for the treatment of diseases including cancer, immune disorders, and infectious disease.
Claims15
A recombinant oncolytic herpes simplex virus (HSV) comprising a nucleic acid encoding an anti-CD47 antibody, wherein the anti-CD47 antibody is an IgG1 isotype, and wherein the nucleic acid encoding the anti-CD47 antibody comprises:
- a sequence of SEQ ID NO:3 encoding a light chain variable region, a sequence of SEQ ID NO:6 encoding a heavy chain variable region, a sequence of SEQ ID NO:
- 4 encoding a light chain constant region, and a sequence of SEQ ID NO:7 encoding a heavy chain constant region CH1.
Dependencies are inferred from the claim text.