Antigen-binding molecules that bind to Porphyromonas gingivalis
AssigneeK-Bio Investment, LLC
InventorsPeter L. Nara, Daniel L. Sindelar
Life of this patent
Estimating the term…
Abstract
Antigen-binding molecules (ABMs) that bind to Porphyromonas gingivalis are described. The ABMs may be human or humanized ABMs. The ABMs find use in treating infections involving P. gingivalis, such as periodontal disease. Also provided are methods of treating or preventing a disorder or disease by administering the ABM.
Claims35
An antigen-binding molecule that binds to Porphyromonas gingivalis, wherein the antigen-binding molecule comprises:
- a heavy chain comprising a heavy chain variable region (HVR) comprising an HVR complementarity determining region (HCDR) 1, an HCDR2, and an HCDR3 from the sequence of SEQ ID NO:9 or 37 per the Kabat or Chothia definition of CDRs;
- and
- a light chain comprising a light chain variable region (LVR) comprising an LVR complementarity determining region (LCDR) 1, an LCDR2, and an LCDR3 from the sequence of SEQ ID NO:10 or 38 per the Kabat or Chothia definition of CDRs;
- wherein the heavy chain comprises an amino acid other than lysine at position 105 as numbered according to the numbering as provided in the sequence of SEQ ID NO:
- 172;
- and
- wherein the heavy chain comprises an amino sequence at least 80% identical to the sequence of SEQ ID NO:263 and the light chain comprises an amino sequence at least 80% identical to the sequence of SEQ ID NO:253.
An antigen-binding molecule that binds to Porphyromonas gingivalis, wherein the antigen-binding molecule comprises a heavy chain and a light chain, wherein the heavy chain comprises the sequence of any one of SEQ ID NOs:
- 245, 247, 249, 251, 261, 263, 265, and 267 and the light chain comprises the sequence of any one of SEQ ID NOs:
- 253, 255, 257, and 259.
An antigen-binding molecule that binds to Porphyromonas gingivalis, wherein the antigen-binding molecule comprises a heavy chain and a light chain, wherein the heavy chain comprises the sequence of SEQ ID NO:263 and the light chain comprises the sequence of SEQ ID NO:253.
An antigen-binding molecule that binds to Porphyromonas gingivalis, wherein the antigen-binding molecule comprises a heavy chain and a light chain, wherein the heavy chain comprises the sequence of SEQ ID NO:263 and the light chain comprises the sequence of SEQ ID NO:357.
Dependencies are inferred from the claim text.