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US 12,637,502 B2Granted
Netrin G1 polypeptides
AssigneeInstitute For Cancer Research
InventorsEdna Cukierman, Ralph Francescone, Debora Vendramini-Costa, Kristopher Raghavan, Janusz Franco-Barraza, Roland Dunbrack
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Abstract
The present disclosure provides polypeptides of netrin G1 (NetG1) and its cell surface receptor netrin G1 ligand (NGL1), and antibodies thereto, and methods of making such antibodies. The disclosure also provides uses of these NetG1 and NGL1 polypeptides, and antibodies thereto, in methods of treating cancers and diseases, including chronic fibrosis, inflammation, and inflammation-related diseases.
Claims6
An isolated Netrin G1 (NetG1) polypeptide comprising a NetG1 peptide moiety of up to 20 amino acids wherein:
- the NetG1 peptide moiety comprises:
- SEQ ID NO:
- 1, SEQ ID NO:
- 16, SEQ ID NO:
- 17, SEQ ID NO:
- 18, SEQ ID NO:2, SEQ ID NO:
- 19, SEQ ID NO:9, SEQ ID NO:22, SEQ ID NO:23, SEQ ID NO:24, SEQ ID NO:
- 10, SEQ ID NO:25, SEQ ID NO:
- 14, SEQ ID NO:26, SEQ ID NO:
- 15, or SEQ ID NO:27;
- and
- wherein the NetG1 polypeptide is linked or fused to a heterologous polypeptide or is labeled with a detectable label.
9 more elements
Dependencies are inferred from the claim text.