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US 12,637,500 B2Granted
Tumor antigen peptide
AssigneeNiigata University
InventorsToshihiko Torigoe, Takayuki Kanaseki, Vitaly Kochin, Yasuhiro Kikuchi
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AssigneeNiigata University
InventorsToshihiko Torigoe, Takayuki Kanaseki, Vitaly Kochin, Yasuhiro Kikuchi
Estimating the term…
The object of the present invention is to provide a detecting agent for specifically detecting a tumor cell, a tumor antigen peptide-specifically presented on a tumor cell, a pharmaceutical composition useful for the prevention and/or treatment of cancer, the pharmaceutical composition containing the tumor antigen peptide as an active ingredient, etc. The above object has been achieved by a tumor antigen peptide or its motif-substituted product, the tumor antigen peptide comprising 8 to 14 consecutive amino acids in an amino acid sequence of a protein encoded by a gene selected from the group consisting of PVT1, SUV39H2, ZNF724P, SNRNP40, and DYRK4, the tumor antigen peptide having an HLA binding ability.
A vaccine composition comprising (a) or (b) below as an active ingredient, an adjuvant, and a pharmaceutically acceptable carrier:
A vaccine composition comprising any one of (a)-(c) below as an active ingredient, an adjuvant, and a pharmaceutically acceptable carrier:
An HLA multimer comprising an HLA and a tumor antigen peptide according to any one of SEQ ID NOs:
An agent for inducing a cytotoxic T cell, the agent comprising a protein encoded by a gene selected from the group consisting of SUV39H2, ZNF724P, SNRNP40, and DYRK4, or a polynucleotide encoding said protein, an adjuvant, and a pharmaceutically acceptable carrier.
An agent for inducing a cytotoxic T cell, the agent comprising an antigen-presenting cell presenting a tumor antigen peptide according to any one of SEQ ID NOS:
A pharmaceutical composition comprising a protein encoded by a gene selected from the group consisting of SUV39H2, ZNF724P, SNRNP40, and DYRK4, or a polynucleotide encoding said protein, an adjuvant, and a pharmaceutically acceptable carrier.
An agent for inducing a cytotoxic T cell, the agent comprising an expression vector comprising a polynucleotide encoding a tumor antigen peptide that comprises SEQ ID NO:
An agent for inducing a cytotoxic T cell, the agent comprising an antigen-presenting cell comprising an expression vector containing a polynucleotide encoding the tumor antigen peptide according to any one of SEQ ID NOs:
A pharmaceutical composition comprising an expression vector comprising a polynucleotide encoding a tumor antigen peptide that comprises SEQ ID NO:
Dependencies are inferred from the claim text.