AAV capsid chimeric antigen receptors and uses thereof
AssigneeUniversity of Massachusetts
InventorsAllison Keeler-Klunk, Terence Flotte, Motahareh Arjomandnejad
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Abstract
Aspects of the disclosure relate to compositions and methods for modulating the immune response of a subject (e.g., a human subject) to certain viral antigens (e.g., antigens derived from AAV capsid proteins). The disclosure is based, in part, on isolated nucleic acids and expression constructs encoding chimeric antigen receptors (CARs) that target AAV capsid proteins, and recombinant immune cells comprising such constructs (e.g., recombinant T-cell comprising a CAR (CAR T-cells), and recombinant T-regulatory cells comprising a CAR (CAR T-regs)).
Claims16
An isolated nucleic acid comprising an expression construct encoding a chimeric antigen receptor (CAR), wherein the CAR comprises:
- (i) an antigen binding domain comprising the amino acid sequence set forth in SEQ ID NO:
- 39;
- (ii) a transmembrane domain;
- and
- (iii) a cytoplasmic signaling domain.
A vector comprising a nucleic acid encoding a CAR having the sequence as set forth in SEQ ID NO:
- 1.
Dependencies are inferred from the claim text.