Heterocyclic compounds, compositions, methods of preparation and uses thereof

A compound of formula (I)

• wherein
• R1 is a group selected from C1-6-alkyl, C1-6-haloalkyl, C1-6-perhaloalkyl, (CH2)mOR′, (CH2)mN(R′)2, 6- to 13-membered aryl, 5- to 11-membered heteroaryl, 3- to 12-membered cycloalkyl, and 3- to 10-membered heterocyclyl, and said group being optionally substituted with one to six substituent(s) each independently selected from R11;
• R2 is a group selected from C1-6-alkyl, C1-6-haloalkyl, C1-6-perhaloalkyl, (CH2)mOR′, (CH2)mN(R′)2, 6- to 13-membered aryl, 5- to 11-membered heteroaryl, 3- to 12-membered cycloalkyl, and 3- to 10-membered heterocyclyl, and said group being optionally substituted with one to six substituent(s) each independently selected from R12;
• or
• R1 and R2, together with the ring nitrogen atom they are attached to, form a 4- to 11-membered unsaturated or aromatic heterocycle or a 4- to 10-membered saturated or partially unsaturated heterocycle, and said heterocycle being optionally substituted with one to six substituent(s) each independently selected from R13;
• R3 is a group selected from 6- to 13-membered aryl, 5- to 11-membered heteroaryl, 3- to 12-membered cycloalkyl, and 3- to 10-membered heterocyclyl, and said group being optionally substituted with one to six substituent(s) each independently selected from R31;
• R11 is selected from halogen, CN, C1-6-alkyl, C1-6-alkoxy, C1-6-(per)haloalkyl, C1-6-(per)haloalkoxy, OR′, oxo, (OCH2)nOR′, SR′, NO2, N(R′)2, (CH2)nN(R′)2, (CH2)nOR′, CH(XR′)R′, CO2R′, C(O)N(R′)2, C(O)NR′C(O)R″, NR′COR″, C(═NH)R″, C(═N—OR′)R″, C(O)R″, NR′C(O)NR″, NR′SO2R″, SO2NHSO2R″, and SO2N(R′)2 and being optionally substituted with one or more substituents each independently selected from the group consisting of R′, OR′, N(R′)2;
• R12 is selected from halogen, CN, C1-6-alkyl, C1-6-alkoxy, C1-6-(per)haloalkyl, C1-6-(per)haloalkoxy, OR′, oxo, (OCH2)nOR′, SR′, NO2, N(R′)2, (CH2)nN(R′)2, (CH2)nOR′, CH(XR′)R′, CO2R′, C(O)N(R′)2, NHCOR″, C(═NH)R″, C(═N—OR′)R″, C(O)R″, and SO2N(R′)2 and being optionally substituted with one or more substituents each independently selected from the group consisting of R′, OR′, N(R′)2;
• R13 is selected from halogen, CN, C1-6-alkyl, C1-6-alkoxy, C1-6-(per)haloalkyl, C1-6-(per)haloalkoxy, OR′, oxo, (OCH2)nOR′, SR′, NO2, N(R′)2, (CH2)nN(R′)2, (CH2)nOR′, CH(XR′)R′, CO2R′, C(O)N(R′)2, C(O)NR′C(O)R″, NR′C(O)R″, C(═NH)R″, C(═N—OR′)R″, C(O)R″, NR′C(O)NR″, NR′SO2R″, SO2NHSO2R″, and SO2N(R′)2 and being optionally substituted with one or more substituents each independently selected from the group consisting of R′, OR′, N(R′)2;
• R31 is selected from halogen, CN, C1-6-alkyl, C1-6-alkoxy, C1-6-(per)haloalkyl, C1-6-(per)haloalkoxy, OR′, oxo, (OCH2)nOR′, SR′, NO2, N(R′)2, (CH2)nN(R′)2, (CH2)nOR′, CO2R′, C(O)N(R′)2, C(O)NR′C(O)R″, NR′C(O)R″, C(═NH)R″, C(═N—OR′H)R″, C(O)R″, NR′C(O)NR″, NR′SO2R″, SO2NHSO2R″, and SO2N(R′)2 and being optionally substituted with one or more substituents each independently selected from the group consisting of R′, OR′, N(R′)2;
• each R′ is independently selected from H, C1-6-alkyl, C1-6-haloalkyl, and C1-6-perhaloalkyl, or when part of any N(R′)2 both R's, together with the nitrogen they are attached to, may form a 3- to 6-membered aliphatic or aromatic heterocyclic ring comprising 1 to 4 heteroatoms each independently selected from N, S, and O;
• each R″ is independently selected from C1-6-alkyl, C1-6-haloalkyl, and C1-6-perhaloalkyl;
• X is O or S;
• m is 0-6;
• and
• n is 1-6;
• or
• a salt, solvate or solvate of a salt thereof.