Carboxylic acid, acyl sulfonamide and acyl sulfamide-derivatized bicyclic aza-heteroaromatics as selective mcl-1 inhibitors and as dual mcl-1/bcl-2 inhibitors

A compound of formula (I), or a pharmaceutically acceptable salt, solvate, hydrate, cocrystal, or prodrug thereof:

• wherein:
• A is
• L is selected from —C(O)O—, —OC(O)—, —C(O)NRa—, —NRaC(O)—, —C(O)NRaSO2—, —SO2NRaC(O)—, —C(O)NRaSO2NRa—, and —NRaSO2NRaC(O)—;
• and
• R, R1, and Ra are independently selected at each occurrence from H, halogen, optionally substituted alkyl, optionally substituted alkylaryl, optionally substituted alkylhetaryl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted cycloalkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted haloalkyl, optionally substituted alkoxy, and optionally substituted heteroaryl;
• and
• Z is a group selected from:
• wherein Ar is
• wherein X is Cl.