Cyclic amine derivatives having serotonin receptor binding activity

A compound represented by Formula (I):

• wherein R1 is substituted or unsubstituted 5-membered aromatic heterocyclyl or substituted or unsubstituted 6-membered aromatic heterocyclyl;
• R2 is each independently a hydrogen atom, halogen, hydroxy, substituted or unsubstituted alkyl, or substituted or unsubstituted alkyloxy;
• R3 is each independently a hydrogen atom, halogen, hydroxy, substituted or unsubstituted alkyl, or substituted or unsubstituted alkyloxy;
• n is 1 or 2;
• a combination of (L1, L2) is (NH, N) or (CH2, N);
• R4 is a group represented by Formula:
• wherein p and q are each 2;
• p″ and q″ are each independently 1 or 2;
• Ra is a hydrogen atom, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted non-aromatic carbocyclyl, or substituted or unsubstituted non-aromatic heterocyclyl;
• Ra″ is a hydrogen atom, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted non-aromatic carbocyclyl, or substituted or unsubstituted non-aromatic heterocyclyl;
• Xb is each independently CRbRb′;
• Xc is each independently CRcRc′;
• Rb is each independently a hydrogen atom, halogen, substituted or unsubstituted alkyl, or substituted or unsubstituted alkyloxy;
• Rb′ is each independently a hydrogen atom, halogen, substituted or unsubstituted alkyl, or substituted or unsubstituted alkyloxy;
• Rc is each independently a hydrogen atom, halogen, substituted or unsubstituted alkyl, or substituted or unsubstituted alkyloxy;
• Rc′ is each independently a hydrogen atom, halogen, substituted or unsubstituted alkyl, or substituted or unsubstituted alkyloxy;
• Rb″ is a hydrogen atom, halogen, substituted or unsubstituted alkyl, or substituted or unsubstituted alkyloxy;
• Rc″ is a hydrogen atom, halogen, substituted or unsubstituted alkyl, or substituted or unsubstituted alkyloxy;
• Xd is CRd or N;
• Xd″ is CRd or N;
• Rd is a hydrogen atom, halogen, cyano, substituted or unsubstituted alkyl, or substituted or unsubstituted carbamoyl;
• Rb and Rb′ and Rc and Rc′ may be taken together with the same carbon atom to which they are bonded to form a substituted or unsubstituted non-aromatic carbocycle or a substituted or unsubstituted non-aromatic heterocycle;
• Ra, and Rb bonded to a carbon atom adjacent to a nitrogen atom to which Ra is bonded may be taken together with the nitrogen atom to which Ra is bonded and the carbon atom to which Rb is bonded to form a substituted or unsubstituted non-aromatic heterocycle;
• or
• Ra, and Rc bonded to a carbon atom adjacent to a nitrogen atom to which Ra is bonded may be taken together with the nitrogen atom to which Ra is bonded and the carbon atom to which Rc is bonded to form a substituted or unsubstituted non-aromatic heterocycle;
• Rb and Ro may be taken together to form a (C1-C3) bridge, wherein one of the carbon atoms constituting the bridge may be replaced with an oxygen atom;
• Ra and Rd may be taken together to form a (C1-C3) bridge, wherein one of the carbon atoms constituting the bridge may be replaced with an oxygen atom;
• R5 and R6 are each independently a hydrogen atom, halogen, hydroxy, substituted or unsubstituted alkyl, or substituted or unsubstituted alkyloxy;
• or
• R5 and R6 may be taken together with the same carbon atom to which they are bonded to form a substituted or unsubstituted non-aromatic carbocycle;
• R7 is a group represented by Formula:
• wherein A is CR11 or N;
• R9 is substituted or unsubstituted alkyloxy, substituted or unsubstituted amino, substituted or unsubstituted aromatic carbocyclyloxy, substituted or unsubstituted alkyl, substituted or unsubstituted non-aromatic carbocyclyl, or cyano;
• R10 is a hydrogen atom, halogen, hydroxy, substituted or unsubstituted alkyl, or substituted or unsubstituted alkyloxy;
• or
• R9 and R10 may be taken together to form a substituted or unsubstituted non-aromatic carbocycle or a substituted or unsubstituted non-aromatic heterocycle;
• R11 is each independently a hydrogen atom, halogen, hydroxy, substituted or unsubstituted alkyl, or substituted or unsubstituted alkyloxy;
• provided that the following compounds are excluded:
• or a pharmaceutically acceptable salt thereof.