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US 12,637,439 B2Granted
Preparation of cannabichromene and related cannabinoids
AssigneeBaymedica, Inc.
InventorCharles K. Marlowe
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Abstract
Methods for the production of cannabichromene and related cannabinoid compounds are disclosed. The methods include: forming a reaction mixture comprising 3,7-dimethylocta-2,6-dienal, a diamine, and olivetol or a related starting material; and maintaining the reaction mixture under conditions sufficient to form the desired product. Methods of the present disclosure may also include one-pot conversion of cannabichromene-type products to cannabinol-type products.
Claims31
A method for preparing a compound according to Formula I:
- or a salt thereof, the method comprising:
- forming a reaction mixture comprising 3,7-dimethylocta-2,6-dienal, a diamine, and a compound of Formula II:
- and
- maintaining the reaction mixture under conditions sufficient to form the compound of Formula I;
- wherein:
- R1 is selected from the group consisting of C1-C20 alkyl, C1-C20 haloalkyl, C1-C20 hydroxyalkyl, deuterated C1-C20 alkyl, tritiated C1-C20 alkyl, and C2-C20 alkenyl;
- R2 is selected from the group consisting of H and —COOR2a;
- and
- R2a is selected from the group consisting of H and C1-C6 alkyl.
6 more elements
Dependencies are inferred from the claim text.