Salt of arylaminoquinazoline-containing compound, and preparation method therefor and use thereof
AssigneeCspc Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd.
InventorsFugang Zhou, Yuxia He, Yan Zhang, Jian Lyu, Kai Shi, Huifeng Di, Xinxin Yang, Jing Sun
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Abstract
Provided are a salt of an arylaminoquinazoline-containing compound as shown in formula 2, a solvate or hydrate thereof, a preparation method therefor and the use thereof. The prepared salt has good crystallinity, and compared to a compound in a free form, the water solubility is significantly improved, and preferably, the salt form and crystal form can stably exist. Therefore, compared to a compound in a free form or other salts, the salt has better druggability.
Claims12
A crystalline form of a salt of an arylaminoquinazoline-containing compound represented by Formula 2 or a hydrate thereof:
- wherein,
- HA is hydrochloric acid;
- n is 2;
- and
- the crystalline form of the salt of the arylaminoquinazoline-containing compound is a crystalline form I of a dihydrochloride salt represented by Formula 3-1 and having characteristic peaks at the following 2θ angles (°):
- 9.8±0.2°, 12.4±0.2°, 18.8±0.2°, 20.3±0.2°, and 24.6±0.2° in an X-ray powder diffraction spectrum with Cu-Kα radiation,
- or
- the crystalline form of the salt of the arylaminoquinazoline-containing compound is a crystal of a dihydrochloride salt tetrahydrate represented by Formula 3-2 and having characteristic peaks at the following 2θ angles (°):
- 6.0±0.2°, 6.8±0.2°, 12.4±0.2°, 15.5±0.2°, 25.4±0.2°, and 26.0±0.2° in an X-ray powder diffraction spectrum with Cu-Kα radiation,
Dependencies are inferred from the claim text.