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US 12,637,431 B2Granted
Process for the preparation of 5-[[[(2S)-2-amino-3-[4-(aminocarbonyl)-2,6-dimethylphenyl]-1-oxopropyl] [(1S)-1-(4-phenyl-1H-imidazol-2-yl)ethyl]amino] methyl-2-methoxybenzoic acid and its polymorphs thereof
AssigneeMsn Laboratories Private Limited, R&D Center
InventorsSrinivasan Thirumalai Rajan, Eswaraiah Sajja, Rajeshwar Reddy Sagyam, Prabhakar Macharla, Rajesham Boge
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Abstract
The present invention relates to an improved process for the preparation of 5-[[[(2S)-2-amino-3-[4-(aminocarbonyl)-2,6-dimethylphenyl]-1-oxopropyl][(1S)-1-(4-phenyl-1H-imidazol-2-yl)ethyl]amino]methyl]-2-methoxybenzoic acid compound of formula-1, and polymorphs thereof, the compound of formula-1 is further represented by the following structural formula:
Claims5
A process for the preparation of amorphous form of Eluxadoline, comprising:
- a) providing a solution of Eluxadoline 2-butanol solvate in a solvent, and
- b) isolating amorphous form of Eluxadoline.
Dependencies are inferred from the claim text.