Oxidized lappaconitine derivative and use thereof
AssigneeQgenetics Co., Ltd.
InventorsMun Seog Chang, Tae Hee Lee, Ha Young Kim, Jung Bin Min
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Abstract
The present invention relates to a novel lappaconitine derivative and a pharmaceutically acceptable salt thereof, a preparation method therefor, and a medical use thereof using osteogenesis-promoting activity. The lappaconitine derivative induces the differentiation of stem cells into preosteoblasts, and increases bone density when administered to an osteoporosis animal model, and induces osteogenesis, and thus can be effectively used for preventing, alleviating, or treating bone-related diseases such as osteoporosis.
Claims9
A compound represented by the following Formula 1, and a stereoisomer, a hydrate, or a pharmaceutically acceptable salt thereof:
A pharmaceutical composition for treating a bone-related disease, comprising a compound represented by the following Formula 1, and a stereoisomer, a hydrate, or a pharmaceutically acceptable salt thereof as an active ingredient, wherein the bone-related disease is selected from the group consisting of osteoporosis, bone fractures, osteomalacia, osteopenia, bone atrophy, osteoarthritis, bone defects, osteolysis, and osteonecrosis:
A method of synthesizing a compound represented by the following Formula 1, comprising:
- allowing lappaconitine to react with an oxidizing agent:
Dependencies are inferred from the claim text.