Method for separation of methionine sulfoxide diastereomers
AssigneesThe Regents of the University of California, Caltech
InventorsJevgenij Raskatov, Scott C. Virgil
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Abstract
A method of separating a compound having methionine oxide diastereomers, including: loading a diastereomeric mixture into a chromatography column, the diastereomeric mixture of a compound having a plurality of methionine oxide diastereoisomers. The method also includes passing a mobile phase, the mobile phase including a supercritical fluid, through the chromatography column to separate the compound based on each methionine oxide diastereoisomer of the plurality of methionine oxide diastereoisomers in the chromatography column.
Claims11
A method for producing a diastereomerically pure methionine sulfoxide composition, the method comprising:
- loading a diastereomeric mixture of compositions that contain S-methionine sulfoxide (Met-(S)—SO) Aβ42 and R-methionine sulfoxide (Met-(R)—SO) Aβ42 onto a chromatography column;
- and
- passing a mobile phase, the mobile phase including a supercritical fluid, through the chromatography column to separate the compositions that contain Met-(S)—SO Aβ42 from those that contain Met-(R)—SO Aβ42 using the chromatography column, thereby producing the diastereomerically pure methionine sulfoxide composition.
Dependencies are inferred from the claim text.