Arylamides and methods of use thereof

A compound of formula I:

• or a pharmaceutically acceptable salt thereof, wherein:
• A is selected from
• wherein * marks the point of attachment to Y and ** marks the point of attachment to —C(O)—;
• Z1, Z2, and Z3 are each independently CR10 or N;
• Z4 and Z5 are each independently O or S;
• Y is a bond, —NR3—, —O—, —S—, or —C(R4)2—;
• E is C2-6-alkynyl, C3-9-cycloalkyl, C4-9-cycloalkenyl, C6-10-aryl, 3-10 membered heteroaryl, or a 3-9 membered heterocycloalkyl, each of which is optionally substituted with one, two, three, four, or five occurrences of R5;
• V is —C(O)—O—R7;
• R1 is adamantyl optionally substituted with one, two, three, four, or five occurrences of Rd;
• each Rd is independently —OH, —NH2, —N═CH(NH2)2, halo, C1-4-alkyl, —O—C1-6-alkyl, —O—C1-6-alkyl-OH, —C1-6-alkyl-OH, —C1-6 haloalkyl, —O—C1-6-haloalkyl, —C1-6-alkyl-OH, —C1-6-alkyl-COOH, —C1-6-alkyl-C(O)2—C1-6-alkyl, —O—C1-6-alkyl-C(O)—C1-6-alkyl, —O—C1-6-alkyl-O—C1-6-alkyl, —O—C1-6-alkyl-C(O) OH, —O—C1-6-alkyl-C(O)O—C1-6-alkyl, or-O—C1-6-alkyl-S(O)—O—C1-6-alkyl;
• each R2 is independently halo, —OH, —NH2, —N—(C1-6-alkyl)2, C1-6-alkyl, C1-6-haloalkyl, —O—C1-6-alkyl, —O—C1-6-alkyl-OH, —O—C1-6-alkyl-O—C1-6-alkyl, —O—C2-6-alkenyl, or C6-10-aryl;
• R3 is hydrogen or C1-6 alkyl;
• R4 is independently hydrogen or C1-6 alkyl;
• each R5 is independently halo, —CN, —NO2, —SF3, —SF5, C1-6-alkyl, C2-6-alkenyl, C1-6-haloalkyl, —O—C1-6-alkyl, —O—C1-6-haloalkyl, —C1-6-alkyl-OH, —C(O)—O—C1-6-alkyl, —S—C1-6alkyl, —S—C1-6-haloalkyl, —S(O)2-C1-6-alkyl, —S(O)2-C1-6-haloalkyl, C6-10-aryl, or —C3-9-cycloalkyl;
• or two R5 moieties, taken together with the atoms to which they are attached, form a 3-9 membered heterocycloalkyl ring, wherein each aryl, cycloalkyl, or heterocycloalkyl is substituted with one, two, or three occurrences of R8;
• each R6 and R10 is independently hydrogen, halo, C1-6-alkyl, or —O—C1-6-alkyl;
• R7 is hydrogen, C1-6-alkyl, C6-10-aryl, or benzyl;
• each R8 is independently halo or C1-6-alkyl;
• R9 is hydrogen, C1-6 alkyl or oxo;
• and
• m is 0, 1, or 2.