Radiohalogen prosthetic moieties and radiolabeled biomolecules
AssigneeDuke University
InventorsMichael Rod Zalutsky, Ganesan Vaidyanathan, Darryl Lynn McDougald
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Abstract
The application is drawn to radiohalogen prosthetic moieties and precursors thereof and to radiolabeled biomolecules comprising such radiohalogen prosthetic moieties. The biomolecules have an affinity for particular types of cells and may specifically bind a certain cell, such as a cancer cell. Relevant biomolecules include antibodies, monoclonal antibodies, antibody fragments, peptides, other proteins, nanoparticles, aptamers, and pharamacological moieties used to target prostate-specific membrane antigen (PSMA).
Claims18
A radiohalogen prosthetic moiety or precursor thereof represented by the following formula:
- wherein:
- Y is a radioactive halogen or a trialkyl tin precursor to a radioactive halogen.
A radiohalogen prosthetic moiety or precursor thereof represented by the following formula:
- wherein Y is a radioactive halogen.
A radiohalogen prosthetic moiety represented by the following formula:
- wherein Y is a radioactive halogen.
Dependencies are inferred from the claim text.