US 12,636,473 B2Granted

Drug delivery system and method

OwnerRuth Sahler, Steven Edward Smathersinventors

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Abstract

A customizable drug delivery system and method utilizing a laser pattern generator (LPG) to define application of a drug delivery payload (DDP) contained within a drug delivery device (DDD) to a drug delivery target (DDT) is disclosed. A computer control device (CCD) supervises the LPG to select a drug payload pathway (DPP) from a drug pathway database (DPD) and writes the selected DPP to the DDD. This pathway patterning process (PPP) modifies the hydrophilic properties of the DDD and enables the DDD to selectively attract and absorb the DDP. The DDD is then injected with the DDP or exposed for drug exposure time (DET) by the CCD and DPD during which the DPP written to the DDD absorbs a controlled amount of DDP. The DDD when subsequently inserted into a drug delivery target (DDT) delivers the DDP to the DDT under controlled delivery rates defined by the DPP and the DET.

Claims20

Dependent claims

A drug delivery method comprising:

(1) selecting a drug delivery device (DDD);
(2) selecting a drug delivery payload (DDP);
(3) with a computer control device (CCD), selecting a drug payload pathway (DPP) from a drug pathway database (DPD);
(4) with said CCD, imprinting the selected DPP onto DDD using a femtosecond laser radiation source (FLS) controlled by a laser pattern generator (LPG);
(5) injecting and/or time exposing said patterned DDD to and/or with said drug delivery payload (DDP);
and
(6) applying said injected and/or time exposed DDD to a drug delivery target (DDT);
wherein:
said CCD is configured to generate hydrophilic modification of said DDD in response to said imprinting of said DDD with said DPP by said CCD;
said LPG is configured to create hydrophilic DPP in said DDD that leads to the surface of said DDD, thereby creating hydrophilic channels within said DDD;
said CCD is configured to expose said imprinted DDD to said DDP based on a predetermined drug exposure profile (DEP);
and
said hydrophilic modification of said DDD permits said DDP to be wicked to or from said DDD based on said DPP imprinted into said DDD.

10 more elements

Dependencies are inferred from the claim text.

Facts

Application: 18/244,609Filed 11 Sep 2023 · division
Priority: 21 Dec 2018
Published: US 2023/0414909 A128 Dec 2023
Granted: 26 May 2026
Term ends: Not estimatedThe source records don’t support an estimate.

Classification14 codes

A61F 2/16
Eye parts, e.g. lenses or corneal implants; Artificial eyes: intraocular lenses
A61M 31/002
Devices for introducing or retaining media, e.g. remedies, in cavities of the body: devices for releasing a drug at a continuous and controlled…
A61F 9/0017
Introducing ophthalmic products into the ocular cavity or retaining products therein: implantable in, or in contact with, the eye, e.g. ocular inserts
A61F 2250/0068
Means for introducing or releasing pharmaceutical products into the body: the pharmaceutical product being in a reservoir

Family

Application62/783,320Us provisional application · filed 21 Dec 2018
Application16/717,131Parent of this division · filed 17 Dec 2019
US 2023/0414909 A1Pre-grant publication · published 28 Dec 2023
US 11,779,739 B2Parent of this division
US 2020/0203023 A1Published application
US 12,636,473 B2This patent

From the US filing history. Foreign family members aren’t listed.