Regional citrate anticoagulation infusion system, control method and system, and medium

A module for controlling an infusion rotation speed of a calcium pump, comprising:

• a calcium pump speed control module, for controlling the infusion rotation speed of the calcium pump according to an amount of calcium supplementation required for a regional citrate anticoagulation infusion system, which is referred to as Qca;
• and
• a calcium supplementation determination module coupled to the calcium pump speed control module,
• wherein upon being in a post-dilution CVVHD mode, the calcium supplementation determination module is configured to:
• calculate an amount of calcium supplementation required in each stage of a two-stage calcium supplement model,
• obtain an amount of calcium supplementation required in a first stage, which is referred to as Qca1, wherein
• Qca
• ⁢
• 1
• ⁢
• (
• mmol
• /
• h
• )
• =
• fa
• ×
• Cca_T
• ×
• Cln
• -
• ca
• ×
• 60
• )
• 1000
• +
• fb
• ×
• Csys
• ⁡
• (
• t
• )
• ×
• BW
• ⁡
• (
• kg
• )
• ×
• 25
• ⁢
• %
• ,
• and
• obtain an amount of calcium supplementation required in a second stage, which is referred to as Qca2;
• , wherein
• Qca
• ⁢
• 2
• ⁢
• (
• mmol
• /
• h
• )
• =
• fa
• ×
• Cca_T
• ×
• Cln
• -
• ca
• ×
• 60
• 1000
• ,
• wherein fa is a fraction of dispersable calcium at an upstream of a dialyzer after a citrate infusion at an arterial end, Cca_T is a total calcium concentration at the upstream of the dialyzer after the citrate infusion, Cln-ca is a dispersable calcium clearance, fb is a correlation coefficient between an accumulated calcium concentration and a citrate concentration, Csys (t) is the citrate concentration at different time, and BW is a weight of a patient;
• wherein upon being in an intermittent hemodialysis (iHD) mode, the calcium supplementation determination module is configured to:
• calculate the dispersable calcium clearance CIn-ca after selecting a membrane area for the dialyzer,
• wherein when the membrane area is less than 1.2 m2, Cln-Ca=0.7944×(Qb×0.43+80.5)×(1−Hct)+2.2421+0.46×Quf;
• wherein when the membrane area ranges from 1.2 to 1.8 m2, Cln-Ca=0.7944×(Qb×0.29+95)×(1−Hct)+2.2421+0.46×Quf;
• wherein when the membrane area is greater than 1.8 m2, Cln-Ca=0.7944×(Qb×0.53+75.5)×(1−Hct)+2.2421+0.46×Quf;
• calculating the amount of calcium cleared in extracorporeal circulation per hour, which is referred to as Eca(mmol/L), based on the dispersable calcium clearance Cln-ca, wherein
• Eca (mmol/L)=fa×Cca_T×Cln-ca×60/1000
• wherein the amount of calcium cleared in extracorporeal circulation is the amount of calcium supplementation, Qb is a blood flow velocity, Quf is an ultrafiltration rate, and Hct is a red blood cell hematocrit;
• wherein a fuzzy adaptive tuning PID control is used for the calcium pump, and, according to a response of the system, a fuzzy inference is applied with reference to fuzzy control rules stored in advance in a computer to automatically achieve an optimal adjustment of PID parameters of the calcium pump;
• and
• wherein the calcium pump speed control module is included in a controller of the regional citrate anticoagulation infusion system,
• the Qca is a main input parameter to the controller for controlling the calcium pump, and
• upon applying the fuzzy adaptive tuning PID control, the controller outputs a peristaltic pump controlling electrical signal to the calcium pump, the infusion rotation speed of the calcium pump being automatically adjusted in response to a change in the Qca to keep the infusion rotation speed of the calcium pump stable.