Chitosan dressing for control of gastrointestinal bleeding
AssigneeTricol Biomedical, Inc.
InventorsCole Gannett, Simon J. Mccarthy, Ervelyn Winata
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Abstract
The present invention relates to a biocompatible, foldable, thin profile, low mass and high surface area, chitosan dressing, optionally modified with catechol, and suitable for treating bleeding in a physiological environment, e.g. gastrointestinal tract. The characteristics and structures of the chitosan dressing are provided. Methods of making and using the chitosan dressing are also provided.
Claims19
A chitosan dressing comprising a catechol modified chitosan for use in the treatment of gastrointestinal tract bleeding, wherein the dressing is biocompatible, hemostatic, resists dissolution in gastrointestinal fluid having a pH of between 3.0 to 4.0 at about 37° C. for at least 6 hours, foldable, compressed, and has a thickness that is between about 50 microns to 500 microns, wherein the chitosan dressing adheres to wet gastrointestinal tissue when in a wet condition with an adherence strength between about 1 kPa and 7 kPa and seals and protects a target tissue site for 12 hours, achieves a controlled, slow dissolution from the attachment site over a period of time not exceeding seven (7) days, and has a brown coloration, including a dark brown coloration, and a density that is in the range of about 0.08 g/cm3 to about 1.2 g/cm3.
Dependencies are inferred from the claim text.