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US 12,636,382 B2Granted
Prostate targeting adeno-associated virus serotype vectors
AssigneeUniversity of Massachusetts
InventorsGuangping Gao, Jianzhong Ai, Hong Li, Qiang Wei
Life of this patent
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Abstract
The disclosure relates to compositions and methods for rAAV-mediated delivery of a transgene to a subject. In some embodiments, the rAAV transduces the prostate tissue of a subject. In some embodiments, the methods are useful for treatment of prostate disease (e.g., prostatitis, BPH, prostate cancer).
Claims17
A method for delivering a transgene to prostate tissue, the method comprising:
- administering to prostate tissue of a subject an effective amount of a recombinant adeno-associated virus (rAAV), wherein the rAAV comprises (i) a capsid protein having a serotype selected from the group consisting of AAV5, AAV6.2, AAV7, AAV8, AAV9, and AAVrh.10, and (ii) an isolated nucleic acid comprising a promoter operably linked to a transgene, wherein the rAAV infects cells of the prostate tissue.
A method for treating a prostate disease, the method comprising:
- administering to a subject having or suspected of having a prostate disease an effective amount of rAAV, wherein the rAAV comprises (i) a capsid protein having a serotype selected from the group consisting of AAV5, AAV6.2, AAV7, AAV8, AAV9, and AAVrh.10, and (ii) an isolated nucleic acid comprising a promoter operably linked to a transgene, wherein the rAAV infects cells of the prostate tissue.
A method for treating a prostate disease, the method comprising:
- administering to a subject having or suspected of having a prostate disease an effective amount of a recombinant adeno-associated virus (rAAV) comprising a capsid having a serotype selected from the group consisting of AAV5, AAV6.2, AAV7, AAV8, AAV9, and AAVrh.10, and an isolated nucleic acid comprising a promoter operably linked to a transgene, wherein the transgene encodes miR3a, and wherein the rAAV infects the cells of prostate tissue of the subject, and expresses the miR34a.
Dependencies are inferred from the claim text.