Methods and compositions for increasing transduction efficiency with cell membrane fusion proteins
AssigneesThe University of North Carolina at Chapel Hill, Texas Tech University System
InventorsChengwen Li, R. Bryan Sutton
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Abstract
The invention relates to methods and compositions for increasing introduction (e.g., transduction) efficiency. In particular, the invention relates to methods of increasing introduction (e.g., transduction) efficiency by contacting a host cell with a heterologous agent in the presence of a cell membrane fusion protein or a functional fragment or derivative thereof. The invention further relates to compositions that include a heterologous agent and a cell membrane fusion protein or a functional fragment or derivative thereof.
Claims18
A method of introducing a heterologous agent into a host cell, comprising contacting the host cell with the heterologous agent and a cell membrane fusion protein, wherein the cell membrane fusion protein is a functional fragment of a ferlin protein which is an isolated FerA domain.
Dependencies are inferred from the claim text.