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US 12,636,374 B2Granted
Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof
AssigneePfizer Inc.
InventorsAnnaliesa Sybil Anderson, Caitlyn Gallagher, Jianxin Gu, Isis Kanevsky, Jin-Hwan Kim, Justin Keith Moran, Suddham Singh, Naveen Surendran
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Abstract
The present invention relates to new conjugated capsular saccharide antigens (glycoconjugates), immunogenic compositions comprising said glycoconjugates and uses thereof.
Claims22
An immunogenic glycoconjugate capable of inducing a humoral immune response to Streptococcus pneumoniae (S. pneumoniae) serotype 3 capsular polysaccharide comprising a S. pneumoniae serotype 3 capsular polysaccharide covalently conjugated to a carrier protein (CP) through a spacer and having the general formula:
- wherein X is selected from the group consisting of CH2 (CH2)n′, (CH2CH2O)mCH2CH2, NHCO(CH2)n′, NHCO(CH2CH2O)mCH2CH2, OCH2(CH2)n′ and O(CH2CH2O)mCH2CH2;
- where n′ is selected from 1 to 10 and m is selected from 1 to 4, and wherein X′ is selected from the group consisting of CH2O(CH2)n″CH2C═O and CH2O(CH2CH2O)m′(CH2)n″CH2C═O, where n″ is selected from 0 to 10 and m′ is selected from 0 to 4, and
- wherein said carrier protein is Cross-Reacting Material 197 (CRM197), C5a peptidase from Streptococcus (SCP), diphtheria toxoid (DT), tetanus toxoid (TT), or Haemophilus influenzae protein D (PD).
Dependencies are inferred from the claim text.