Application of microbial glycosidase as an anti-viral therapeutic, prognostic, and diagnostic
AssigneeThe Regents of the University of California
InventorsCameron Martino, Benjamin Kellman, Nathan Lewis, Robin Knight, Jeffrey D. Esko, Daniel Sandoval, Thomas Mandel Clausen
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Abstract
Methods and compositions for diagnosing, preventing or treating a viral infection in a subject comprising administering to a subject in need thereof an effective amount of a glycosidase or a sulfatase to degrade a glycan, such as heparan sulfate, to inhibit viral infection, such as COVID-19. Methods for identifying a glycosidase, a sulfatase, or a microbe associated with increased susceptibility to viral infection in a subject.
Claims5
A method of degrading heparan sulfate comprising administering an effective amount of a composition comprising heparin lyase or a heparin lyase-producing microbe, wherein administration blocks SARS-COV-2 spike protein binding to a mammalian cell surface heparan sulfate.
Dependencies are inferred from the claim text.