# US 12,636,322 B2 · Bacterial strain with high cellulolytic activity

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- Number: US 12,636,322 B2
- Document ID: US12636322B2
- Status: Granted
- Kind: B2
- Application number: 18/570,332
- Filed: 2022-06-24
- Published: 2025-10-16
- Granted: 2026-05-26
- Earliest claimed: 2021-06-25
- Assignees: Institut National Superieur Des Sciences Agronomiques De L'alimentation Et De L'environment; Lab To Field
- Applicants: Institut National Superieur Des Sciences Agronomiques De L'alimentation Et De L'environnement; Lab To Field
- Inventors: Véronique Julliand; Alicia Froidurot; Emmanuel Jacotot; Samy Julliand
- Web page: https://patentgrep.com/patent/US12636322B2

## CPC

- A61K 35/741: Probiotics (probiotic yeast, e.g. saccharomyces A61K36/06)
- A23K 10/18: of live microorganisms
- A23L 33/135: Bacteria or derivatives thereof, e.g. probiotics
- A61K 39/0216: {Bacteriodetes, e.g. Bacteroides, Ornithobacter, Porphyromonas}
- C12N 1/205: Bacterial isolates
- A61K 2035/115: {Probiotics}
- C12R 2001/01: Bacteria or Actinomycetales {; using bacteria or Actinomycetales}
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A23K: FODDER
- A23L: FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF (preservation thereof A23B)
- C12N: MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA (microbiological testing media C12Q1/00)
- C12R: INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS

## Abstract

The present invention concerns a bacterial strain of Fibrobacter succinogenes and a composition thereof, and its use as a probiotic in order to improve the digestive fibrolysis.

## Claims

### Claim 1

A composition comprising an isolated strain of Fibrobacter succinogenes deposited under the accession number DSM 33656, wherein the Fibrobacter succinogenes strain shows cellulolytic activity outside its original environment and wherein the Fibrobacter succinogenes strain is present at a concentration that is adequate to provide a probiotic effect, wherein the composition is an edible composition which is in the form of a cream, granule, paste or pellet.

### Claim 2 (depends on 1)

The composition of claim 1, wherein the composition is an oral composition.

### Claim 3 (depends on 1)

The composition of claim 1, wherein the composition is formulated as a probiotic composition.

### Claim 4 (depends on 1)

The composition of claim 1, wherein the Fibrobacter succinogenes strain has higher extracellular carboxymethylcellulase and xylanase activities compared to Fibrobacter succinogenes S85 strain grown on cellulose.

### Claim 5 (depends on 1)

A method for improving the digestive fibrolysis in a mammalian animal comprising orally administering to said animal the composition of claim 1.

### Claim 6 (depends on 5)

The method of claim 5, wherein the mammalian animal is a human or a non-human animal.

### Claim 7 (depends on 6)

The method of claim 6, wherein the non-human animal is a horse, a sheep, a cow, a goat, or a pig.