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AssigneePaean Biotechnology Inc.
InventorsKyuboem Han, Chun-Hyung Kim, Shin-Hye Yu, Seo-Eun Lee, Sang-Min Lim, Hahnsun Jung, Kwangmin Na, Yoon Mi Han, Jun Young Son, Eun Young Lee, Jeong Yeon Kim, Yeong Wook Song, Jin Chul Paeng, Yun Sang Lee, Do Won Hwang
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The present invention relates to a pharmaceutical composition for preventing or treating myositis. More particularly, the present invention relates to a pharmaceutical composition for preventing or treating myositis, comprising mitochondria as an active ingredient. When the pharmaceutical composition of the present invention comprising exogenous mitochondria as an active ingredient is administered to a subject suffering from myositis, inflammatory cells infiltrated into the muscle cells of the subject can be reduced. In addition, the pharmaceutical composition of the present invention effectively inhibits the expression of IL-1β, TNF-α, and IL-6, inflammatory cytokines. Therefore, the pharmaceutical composition according to the present invention can be usefully used for preventing or treating myositis.
A method for treating myositis, comprising a step of administering to a subject in need thereof a pharmaceutical composition comprising isolated mitochondria as an active ingredient, wherein the myositis is polymyositis or dermatomyositis, wherein the isolated mitochondria are isolated from mesenchymal stem cells.
Dependencies are inferred from the claim text.