Therapeutic agent for short tear breakup time-type dry eye and eye drops containing same
AssigneesKinki University, Nof Corporation
InventorsNoriaki Nagai, Ryotaro Seiriki, Misa Minami, Shunsuke Sakurai, Eiji Harata
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Abstract
A method of treating short tear breakup time-type dry eye, including a step of administering, to a mammal including a human, (i) a copolymer (P) having three kinds of different constituent units represented by formulae (1a) to (1c) and a weight-average molecular weight of from 5,000 to 2,000,000, wherein a molar ratio among the constituent units [(1a)/(1b)/(1c)] in the copolymer (P) is 100/from 10 to 400/from 2 to 50, or (ii) a composition containing the copolymer (P) at a concentration of from 0.001 w/v % to 1.0 w/v %: wherein R1 to R6 are as defined herein.
Claims4
A method of treating short tear breakup time-type dry eye, including the following step:
- a step of administering, to a mammal including a human, a copolymer (P) which comprises constituent units represented by the following formulae (1a) to (1c), has a weight-average molecular weight of from 5,000 to 2,000,000, and has a molar ratio among the constituent units [(1a)/(1b)/(1c)] of 100/from 10 to 400/from 2 to 50, or a composition containing the copolymer (P) at a concentration of from 0.001 w/v % to 1.0 w/v %:
- in the formula (1a), R1 represents a hydrogen atom or a methyl group;
- in the formula (1b), R2 represents a hydrogen atom or a methyl group, and R3 and R4 each independently represent a hydrogen atom, a methyl group, or an ethyl group, or represent a morpholino group by being bonded to each other;
- and
- in the formula (1c), R5 represents a hydrogen atom or a methyl group, and R6 represents a hydrocarbon group having 12 to 24 carbon atoms.
Dependencies are inferred from the claim text.