Methods and materials for diagnosis and treatment of neuronal disorder
AssigneeGenemo Inc.
InventorsZixu Zhou, Qiuyang Wu, Sheng Zhong, Zhangming Yan
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Abstract
Provided herein are methods of managing, preventing, or treating a neuronal disorder in a subject, such as Alzheimer's disease, comprising monitoring the expression level of phosphoglycerate dehydrogenase (PHGDH) in the subject over an observation period of time, and administering to the subject an effective amount of a therapy for managing, preventing or treating the neuronal disorder.
Claims16
A method of managing, or treating a neuronal disorder associated with neuro-excitotoxicity in a subject, comprising
- (a) monitoring the expression level of phosphoglycerate dehydrogenase (PHGDH) in the subject over an observation period of time;
- and
- (b) administering to the subject an effective amount of a therapy for managing or treating the neuronal disorder, if the expression level of PHGDH is increased during the observation period;
- wherein the neuronal disorder is managed or treated in the subject, and the monitoring further comprises:
- providing a series of samples taken from the subject at sequential time points before or during the observation period;
- measuring the expression level of PHGDH using the series of samples;
- and
- determining a longitudinal trend in the expression level of PHGDH.
A method of managing or treating a neuronal disorder associated with neuro-excitotoxicity in a subject who is under an ongoing first therapy for the neuronal disorder, comprising
- (a) monitoring the expression level of phosphoglycerate dehydrogenase (PHGDH) in the subject over an observation period of time;
- (b) administering a second therapy to the subject, if the expression level of PHGDH is increased during the observation period;
- wherein the first therapy and second therapy are different;
- and
- (c) ceasing the ongoing first therapy and administering a third therapy to the subject, if the expression level of PHGDH is not increased during the observation period;
- wherein the neuronal disorder is managed or treated in the subject, the first therapy comprises at least one NMDA receptor antagonist, and the third therapy does not comprise any NMDA receptor antagonist.
A method of diagnosing a neuronal disorder associated with neuro-excitotoxicity in a subject, comprising
- (a) monitoring the expression level of phosphoglycerate dehydrogenase (PHGDH) in the subject over an observation period of time;
- and
- (b) classifying the subject as having the neuronal disorder or at a high risk of developing the neuronal disorder, if the expression level of PHGDH is increased during the observation period;
- or
- (c) classifying the subject as having a low risk of developing the neuronal disorder, if the expression level of PHGDH is increased during the observation period;
- wherein the neuronal disorder is diagnosed in the subject, monitoring the expression level of PHGDH is performed by measuring the amount of extracellular RNA (exRNA) produced from expression of PHGDH in the subject, and the exRNA is produced from transcription of the PHGDH gene.
Dependencies are inferred from the claim text.