Modified release compositions of nafamostat and methods of using same
AssigneeEnsysce Biosciences Inc.
InventorLynn Kirkpatrick
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Abstract
Aspects of the present disclosure include a composition of nafamostat or a pharmaceutically acceptable salt thereof that provides for controlled release of nafamostat or pharmaceutically acceptable salt thereof to a subject for an extended period of time. Compositions according to certain embodiments include a plurality of controlled release beads where each bead includes a core, an active agent layer having nafamostat or a pharmaceutically acceptable salt thereof and a controlled release layer having one or more polymers formulated in an amount sufficient to provide for controlled release of the nafamostat or pharmaceutically 10 acceptable salt thereof. Methods for administering (e.g., orally) the controlled release nafamostat compositions to a subject are also described.
Claims15
A composition comprising nafamostat or a pharmaceutically acceptable salt thereof, wherein the composition provides for controlled release of the nafamostat or pharmaceutically acceptable salt thereof to a subject for an extended period of time, the composition comprising a plurality of controlled release beads, each bead comprising:
- a core;
- an active agent layer comprising nafamostat or a pharmaceutically acceptable salt thereof;
- and
- a controlled release layer comprising one or more polymers formulated in an amount sufficient to provide for controlled release of the nafamostat or pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.