Methods for the use of tissue repair and sealing devices having a detachable graft and clasp assembly

A method for the use of a tissue repair and sealing device in an open (non-MIS) or minimally invasive surgical (MIS) procedure to rapidly repair a tissue fenestration and create a pressure-resistant, watertight seal, comprising:

• (a) selecting a tissue repair and sealing device having a detachable graft and clasp assembly removably attached to an applicator assembly,
• wherein said detachable graft and clasp assembly comprises a graft subassembly having a biodegradable graft that is fixedly attached to a deployable clasp and coupler subassembly having a deployable clasp with radial struts or spokes and a central coupler and
• wherein said applicator assembly comprises an applicator shaft, a clasp retain and release member, and an actuator rod;
• (b) folding the deployable clasp radial struts or spokes and inserting into the clasp retain and release member, wherein the biodegradable graft is positioned outside said clasp retain and release member;
• (c) inserting the graft through a tissue fenestration and positioning the graft on an inner tissue surface;
• (d) positioning the deployable clasp and coupler subassembly on an outer tissue surface;
• (e) deploying the tissue repair and sealing device to controllably release the clasp struts or spokes from the clasp retain and release member to contact the outer tissue surface and secure the graft to the inner tissue surface, repairing the tissue fenestration, and create a pressure-resistant, watertight seal.