Closed-loop drug infusion system with synergic control

A closed-loop system for intravenous automatic multi-infusion of anaesthetic drugs with synergy to patients, the system comprising:

• an infusion pump subsystem configured to deliver to a patient a number of drugs;
• a monitoring subsystem configured to measure a set of physiological variables with patient status information;
• a control subsystem configured to adapt an amount delivered of each drug by the infusion pump subsystem, based on a predetermined initial infusion amount, monitoring target values, a feedback of the measured physiological variables and a multivariable controller with multiple input and multiple output-proportional, integral and derivative (MIMO-PID) synergy between the drugs, wherein the control subsystem comprises:
• a control error generating module configured to calculate errors based on the monitoring target values and the feedback of the measured physiological variables;
• a controller configured to determine a control infusion for each of the drugs based on the errors calculated by the control error generating module and the predetermined initial infusion amount;
• a correction module configured to receive the measurements of the set of physiological variables from the monitoring subsystem and modify the control infusion of the controller, increasing said infusion as a function of an upper threshold or decreasing it as a function of a lower threshold, to set the physiological variables at a preset safe range for the physiological variables;
• a safety module configured to receive the control infusion of each drug and modify said infusion by limiting it between two infusion values, a lower limit and an upper limit, which ensure there is no over-medication for each drug;
• the control error generating module being configured to generate, for each of the variables of the set of physiological variables with patient status information to be measured by the monitoring subsystem, a control vector and wherein the controller comprises a multiple input single output (MISO) control subsystem for each drug, which in turn comprises single input single output (SISO) controllers configured to receive the control errors and determine a control infusion vector for each drug;
• the control subsystem being customized specifically for the patient based on methods of tuning the controller through various gains relative to each SISO controller and at least one physiological parameter specific to the patient including weight, height, sex, muscle mass or clinical history, each MISO control subsystem is multiple input single output control-proportional, integral and derivative control subsystem (MISO-PID), and the SISO controllers include single input single output-proportional, integral and derivative (SISO-PID);
• and
• the control vector of the control error generating module, having a proportional asymmetric error component, an integral symmetric error component, a derivative asymmetric error component and additional error components, and wherein SISO-PIDs are configured to respectively receive the proportional asymmetric error component, the integral symmetric error component and the derivative asymmetric error component of each control vector and determine the control infusion vector for each drug.