Method for reducing measurement interference of micro biosensor

A method for reducing a measurement interference of a target analyte while using a micro biosensor to measure a physiological parameter representative of the target analyte in a biofluid during a period including at least one first sub-time (T1) zone or at least one second sub-time (T2) zone, comprising:

• (a) providing the micro biosensor including a substrate, a first working electrode, at least one second working electrode and a chemical reagent, wherein the first working electrode has a first sensing section, the at least one second working electrode has a second sensing section disposed adjacent to three sides of the first sensing section, the second sensing section extends along the three sides to form a U-shaped sensing section, the first sensing section and the second sensing section are aligned in a same plane on the substrate, the chemical reagent is covered on at least a portion of the first sensing section to react with the target analyte in the biofluid to produce a resultant, the substrate has a surface on which the first working electrode and the at least one second working electrode are configured, the second sensing section extends along and is spaced apart from at least a portion of a periphery of the first sensing section, a ratio of the portion of the periphery of the first sensing section to a total of the periphery of the first sensing section ranges from 30% to 100%, the first sensing section of the first working electrode is driven to form a measurement range, the second sensing section of the at least one second working electrode is driven to form an interference eliminating range, and the interference eliminating range contacts a surrounding of the first sensing section and at least partially overlaps the measurement range;
• (b) performing a first interference eliminating action in a first T1 zone, in which the second sensing section is driven by a second working voltage to consume at least one interferant in the biofluid;
• (c) performing a first measurement action in a first T2 zone, in which the first sensing section is driven by a first working voltage to react with the resultant to output a first physiological signal corresponding to a then-current physiological parameter;
• (d) performing a second interference eliminating action in a second T1 zone, in which the second sensing section is driven by the second working voltage to consume the at least one interferant in the biofluid;
• (e) performing a second measurement action in a second T2 zone, in which the first sensing section is driven by the first working voltage to react with the resultant to output a second physiological signal corresponding to the then-current physiological parameter;
• and
• (f) repeatedly performing step (b) to step (e) to obtain a value data of the physiological parameter in all respective T2 zones during the period, wherein each T1 zone and each T2 zone are at least partially overlapped.