Systems and methods for monitoring intracranial compliance

A method for monitoring intracranial compliance in a patient comprising:

• obtaining, by a processor, a measurement indicative of an intracranial pressure of a patient from an intracranial pressure sensor configured to be implanted in or disposed proximate a skull of the patient;
• obtaining, by a processor, a measurement indicative of a CO2 level of the patient from an end tidal CO2 sensor or a partial pressure of CO2 sensor, wherein the end tidal CO2 sensor or the partial pressure of CO2 sensor is configured to be disposed in an endotracheal tube or a transcutaneous or indwelling vascular catheter;
• determining an intracranial compliance from the measurement indicative of the intracranial pressure and the measurement indicative of the CO2 level of the patient with the processor, wherein the processor is coupled to or in communication with the intracranial pressure sensor and the end tidal CO2 sensor or a partial pressure of CO2 sensor, wherein the intracranial compliance is determined based on a correlation coefficient of the measurement indicative of the intracranial pressure and the measurement indicative of the CO2 level;
• determining a therapy based on the intracranial compliance;
• and
• administering the therapy to the patient, wherein the therapy includes at least one of hypertonic saline, mannitol, opioids, barbiturates, benzodiazepines, Propofol, ketamine, drug-induced coma, therapeutic hypothermia, modification of minute ventilation CO2 target, modification of blood pressure target, diversion of cerebrospinal fluid, and surgical decompression.