US 12,635,715 B2Granted

Isofucosterol and combinations of isofucosterol and a multiplicity of sterols as a nutrient for animals

AssigneesApix Biosciences, Phytant

InventorsThierry Bogaert, Sharoni Shafir, Geraldine Wright, Jan Bogaert

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Abstract

A method for feeding invertebrates or aquaculture organisms, comprising # providing a pollen substitute composition comprising a nutritionally effective amount of isofucosterol, fucosterol or a mixture thereof; and # administering the pollen substitute composition to invertebrates or aquaculture organisms; wherein the pollen substitute composition comprises a nutritionally effective amount at least one further sterol, preferably at least two further sterols selected from the group consisting of cholesterol, 24-Methylene-cholesterol, campesterol, stigmasterol and beta-sitosterol or a physiologically available conjugate of any of these sterols.

Claims32

Dependent claims

A method for feeding invertebrates or aquaculture organisms comprising:

providing a pollen substitute composition comprising a nutritionally effective amount of isofucosterol, fucosterol or a mixture thereof;
and
administering the pollen substitute composition to invertebrates or aquacultural organisms;
wherein the pollen substitute composition comprises a nutritionally effective amount selected from (a) or (b), and wherein (a) and (b) are:
(a) at least one further sterol selected from the group consisting of cholesterol, 24-Methylenecholesterol, campesterol, stigmasterol and beta-sitosterol or a physiologically available conjugate thereof, in a weight-ratio of isofucosterol, fucosterol, or a mixture thereof to the sum of at least one further sterol is from 2:100 to 100:2 and
(b) at least two further sterols, selected from the group consisting of cholesterol, 24-Methylenecholesterol, campesterol, stigmasterol and beta-sitosterol or a physiologically available conjugate thereof in a weight-ratio of isofucosterol, fucosterol, or a mixture thereof to the sum of the at least two further sterols is from 2:100 to 100:2
each as compared to the total weight of the pollen substitute composition.

4 more elements

A pollen-free feed composition or a pollen-substitute composition in particular for bees comprising either

from 0.01 w % to 1 w % isofucosterol, or
from 0.01 w % to 0.3 w % isofucosterol,
each as compared to the total weight of the pollen-substitute composition, wherein the composition optionally further comprises natural pollen in an amount from 1 w % to 15 w % as compared to the total weight of the pollen-substitute composition to increase food consumption;
or
from 0.01 w % to 1 w % fucosterol, or
from 0.01 w % to 0.3 w % fucosterol,
each as compared to the total weight of the pollen-substitute composition, wherein the composition optionally further comprises natural pollen in an amount from 1 w % to 15 w % as compared to the total weight of the pollen-substitute composition to increase food consumption;
or
from 0.01 w % to 1 w % isofucosterol and fucosterol, or
from 0.01 w % to 0.3 w % isofucosterol and fucosterol,
each as compared to the total weight of the pollen-substitute composition, wherein the weight-ratio of isofucosterol to fucosterol is from 0.01:
to 100 to 100:0.01 and
wherein the composition optionally further comprises natural pollen in an amount from 1 w % to 15 w % as compared to the total weight of the pollen-substitute composition to increase food consumption;
or
from 0.01 w % to 1 w % isofucosterol/fucosterol, or
from 0.01 w % to 0.3 w % isofucosterol/fucosterol,
each as compared to the total weight of the pollen-substitute composition,
wherein the weight-ratio of isofucosterol to fucosterol is from 0.01:100 to 100:0.01;
wherein the pollen substitute composition further comprises from 0.01 w % to 0.5 w % 24-methylene-cholesterol as compared to the total weight of the pollen-substitute composition;
wherein the ratio of isofucosterol and fucosterol to 24-methylene-cholesterol is from 2:100 to 100:2;
and
wherein the pollen substitute composition optionally further comprises natural pollen in an amount from 1 w % to 15 w %
each as compared to the total weight of the pollen-substitute composition to increase food consumption;
or
from 0.01 w % to 1 w % 24-methylene-cholesterol, or
from 0.01 w % to 0.3 w % 24-methylene-cholesterol,
each as compared to the total weight of the pollen-substitute composition;
wherein the pollen substitute composition further comprises isofucosterol and fucosterol with a weight-ratio of isofucosterol to fucosterol from 0.01:100 to 100:0.01;
wherein the weight ratio of isofucosterol and fucosterol to 24-methylene-cholesterol is from 2:100 to 100:2;
and
wherein the pollen substitute composition optionally further comprises natural pollen in an amount from 1 w % to 15 w %
each as compared to the total weight of the pollen-substitute composition to increase food consumption.

29 more elements

Dependencies are inferred from the claim text.