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US 12,635,675 B2Granted
Alzheimers disease animal model and use thereof
AssigneeTsinghua University
InventorsBai Lu, Keliang Pang, Wei Guo
Life of this patent
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Abstract
Provided is an Alzheimer's disease rat model or a tissue or cell thereof, which comprises a chimeric APP gene encoding a modified APP and use thereof.
Claims8
A rat or a living part thereof, wherein said rat expresses a modified amyloid precursor protein (APP) as set forth in SEQ ID NO:
- 2, wherein tau pathology and neuronal loss are detectable in said rat or the living part thereof, wherein the tau pathology comprises hyper-phosphorylation of tau protein and aggregation of tau protein.
Dependencies are inferred from the claim text.