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US 12,634,602 B2Granted
Image sensing system and method for imaging
AssigneeVentana Medical Systems, Inc.
InventorUwe Horchner
Life of this patent
Estimating the term…
Abstract
Embodiments described herein pertain to systems and methods for imaging. An imaging system may include a castellated optical element, a CMOS image sensor, and color filtering elements. The CMOS image sensor may include focus areas, a line-scan area, a 2D imaging area, and look-ahead gaps. The imaging system may be configured scan and capture bi-directionally, forward-focused brightfield and fluorescence images of one or more slides comprising at least one biological material.
Claims29
An imaging system, comprising:
- a castellated optical element;
- and
- a complementary metal oxide semiconductor (CMOS) image sensor, wherein the CMOS image sensor comprises:
- a plurality of pixels arranged in a plurality of pixel columns, wherein a first set of columns of the plurality of pixel columns includes a plurality of focus areas, a second set of columns of the plurality of pixel columns includes a line-scan area, and a third set of columns of the plurality of pixel columns includes a two-dimensional imaging area;
- and
- a plurality of color filtering members disposed over at least one of pixels of the line-scan area or pixels of the two-dimensional imaging area, wherein the plurality of color filtering members comprise one or more first color filtering elements, one or more second color filtering elements, and one or more third color filtering elements.
3 more elements
A method for imaging, the method comprising:
- acquiring a plurality of focusing signals of one or more slides comprising at least one biological material with a plurality of focus areas of a CMOS image sensor, wherein a first focus area of the plurality of focus areas receives light, passed through a castellated optical element, from a first focal plane, a second focus area of the plurality of focus areas receives light, passed through the castellated optical element, from a second focal plane, and a third focus area of the plurality of focus areas receives light, passed through the castellated optical element, from a third focal plane;
- scanning the one or more slides with a line-scanning area of the CMOS image sensor;
- and
- capturing an image of the one or more slides with a two-dimensional imaging area of the CMOS image sensor.
1 more element
Dependencies are inferred from the claim text.