Non-invasive assay for detecting and monitoring systemic inflammation

A method for treating a patient with an anti-inflammatory drug,

• the method comprising the steps of:
• determining whether the patient has systemic inflammation by:
• obtaining a urine sample from the patient;
• and
• performing an immunoassay on the urine sample to determine if the urine sample has a presence of a peptide fragment having the amino acid sequence set forth in SEQ ID NO:
• 1—GNYDAAKRGPGGAW thereby providing a urinary proteomic signature of the patient, wherein the immunoassay comprises subjecting the urine sample to antibodies specific to the peptide fragment, and
• wherein the patient is administered with an anti-inflammatory drug if the urinary proteomic signature of the patient corresponds to a control urinary proteomic signature of subjects suffering from the systemic inflammation;
• and
• wherein the patient is not administered with the anti-inflammatory drug if the urinary proteomic signature of the patient does not correspond to the control urinary proteomic signature.