Methods for diagnosing and treating uveitis

A method of diagnosing and treating uveitis in a patient, the method comprising:

• a) obtaining a vitreous sample from an eye of the patient;
• b) measuring levels of expression of at least 3 biomarkers selected from the group consisting of peptidoglycan recognition protein 1 (PGLYRP1), elastase, neutrophil expressed (ELANE), matrix metalloproteinase-9 (MMP9), DNA damage-responsive RNA polymerase-degradation factor (DEF1), S100 calcium binding protein A8 (S100A8), SPARC like 1 protein (SPARCL1), LDL receptor related protein 2 (LRP2), and chondromodulin (CNMD) in the vitreous sample;
• c) diagnosing the patient with infectious uveitis or non-infectious uveitis, wherein increased levels of expression of PGLYRP1, ELANE, MMP9, DEF1, and S100A8compared to reference value ranges for a vitreous sample from a subject having non-infectious uveitis indicate that the patient has infectious uveitis, and decreased levels of expression of SPARCL1, LRP2, and CNMD compared to reference value ranges for a vitreous sample from a subject having infectious uveitis indicate that the patient has non-infectious uveitis;
• and
• d) administering a glucocorticoid steroid, a cycloplegic agent, an antimetabolite, a T-cell inhibitor, an anti-tumor necrosis factor (TNF) agent, a biologic agent, or an alkylating agent to the patient diagnosed with non-infectious uveitis.