Particle assemblies, methods of making and use
AssigneesStemcell Technologies Canada Inc., The University of British Columbia
InventorsRuss Algar, Michael Van Tran
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Abstract
The present application is directed to a composite material comprising a core that is responsive to a magnet or a magnetic field, surrounded by a polymer that has been chemically modified to spontaneously bind and assemble a dense corona of fluorescent quantum dots, which is then over-coated with another layer of modified polymer that can be bound by an antibody complex for targeting specific antigens. Methods of preparing and using this material for the detection and quantification of target antigens is also included in the application.
Claims25
A particle assembly comprising:
- a. a nanoparticle core that is responsive to a magnetic field;
- b. a first polymer coating surrounding the core, the first polymer coating comprising a first polymer, wherein the first polymer comprises imidazole functional groups to bind quantum dots;
- c. a second polymer over-coating external to the first polymer coating, the second polymer over-coating comprising a second polymer wherein the second polymer comprises imidazole functional groups to bind the quantum dots;
- and
- d. a corona of quantum dots surrounding the core wherein the quantum dots are bound to and between the first polymer coating and the second polymer over-coating,
- wherein the particle assembly is cell-compatible,
- wherein the particle assembly has diameter greater than 100 nm, and
- wherein the imidazole groups are covalently bound to the first and second polymers.
Dependencies are inferred from the claim text.