Biotechnological optimization of microorganisms for the 1,2-dehydrogenation of steroids
AssigneeEuroapi France
InventorsClaus Tobias Lattemann, Bernd Janocha, Hans-Falk Rasser, Sebastian Rissom
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Abstract
The present invention concerns a genetically modified bacterium and to its industrial application, in particular in the 1,2-dehydrogenation of steroids.
Claims20
A genetically modified bacterium wherein expression of a gene encoding a 20-beta-hydroxysteroid dehydrogenase (20β-HSDH) is reduced or suppressed compared to a corresponding unmodified bacterium, wherein the corresponding unmodified bacterium has Δ1-dehydrogenase activity and 20-β-hydroxysteroid dehydrogenase activity, and wherein the gene encoding a 20β-HSDH has at least 90% identity to the nucleic acid sequence set forth in SEQ ID NO:
- 1.
Dependencies are inferred from the claim text.