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US 12,630,846 B2Granted
Type I-C CRISPR system from Neisseria lactamica and methods of use
AssigneesThe Regents of the University of Michigan, Cornell University
InventorsYan Zhang, Ailong Ke, Ryan Krueger, Zhonggang Hou
Life of this patent
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Abstract
The disclosure provides a method of altering a DNA sequence, which method comprises the use of a type I-C CRISPR-Cas system based on Neisseria lactamica. The system involves a combination of two or more Neisseria lactamica proteins selected from Cas3, Cas5, Cas8c, and Cas7 and a synthetic guide RNA sequence.
Claims19
A method of altering a target DNA sequence, which method comprises introducing to a target DNA sequence:
- (a) a synthetic guide RNA sequence that is complementary to a target DNA sequence in a host cell;
- and
- (b) a combination of Neisseria lactamica proteins Cas3, Cas5, Cas8c, and Cas7.
Dependencies are inferred from the claim text.