RNAi agents for inhibiting expression of xanthine dehydrogenase (XDH), pharmaceutical compositions thereof, and methods of use

A method of inhibiting Xanthine Dehydrogenase (XDH) gene expression, reducing XDH mRNA expression level, or reducing XDH protein expression level in a cell comprising:

• contacting an RNAi agent to the cell, thereby inhibiting XDH gene expression, reducing XDH mRNA expression level, or reducing XDH protein expression level in the cell,
• wherein the RNAi agent comprising a sense strand and an antisense strand, wherein the sense strand comprises a nucleic acid sequence of cucucucaGfaGfuAfuuauggaa (SEQ ID NO:
• 1663) and the antisense strand comprises a nucleic acid sequence of cPrpusUfscCfauaauac UfcUfgAfgagsasg (SEQ ID NO:
• 1146), wherein lower case (n)=2′-O-Me modified nucleotide;
• Nf=2′-F modified nucleotide;
• cPrpn=5′-cyclopropyl phosphonate-2′-O-methyl modified nucleotide;
• and s=phosphorothioate backbone modification.