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US 12,630,803 B2Granted
Method of increasing proliferation of pancreatic beta cells, treatment method, and composition
AssigneeIcahn School of Medicine at Mount Sinai
InventorsAndrew F. Stewart, Courtney Ackeifi, Peng Wang, Robert J. Devita
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Abstract
Disclosed herein are methods of increasing cell proliferation in a population of pancreatic beta cells. Also disclosed are methods of treating a subject for a condition associated with insufficient insulin secretion. Also disclosed is a composition comprising a DYRK1A inhibitor and a GLP1R agonist. The disclosure further describes a method of regenerating pancreatic beta cells in a transplant patient.
Claims11
A method of treating a subject for a condition associated with insufficient insulin secretion, said method comprising:
- administering to a human subject in need of treatment for a condition associated with an insufficient level of insulin secretion a dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) inhibitor and a glucagon-like peptide-1 receptor (GLP1R) agonist, wherein said administering is carried out under conditions effective to cause an increase in glycemic control in the subject to treat the subject for the condition associated with insufficient level of insulin secretion.
Dependencies are inferred from the claim text.