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US 12,630,649 B2Granted
Compositions and methods for improving tumor penetration of tumor specific antibodies
AssigneeThe Research Foundation for The State University of New York
InventorsJoseph P. Balthasar, Brandon M. Bordeau
Life of this patent
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Abstract
Provided are compositions and methods for improving tumor penetrability of anti-tumor antibodies or conjugates thereof. The method comprises administering to an individual in need of treatment an anti-idiotypic antibody in addition to the anti-tumor antibody or conjugate. Examples are provided for anti-HER2 antibodies and anti-idiotypic antibodies that are directed to the anti-HER2 antibodies.
Claims8
A method for inhibiting the growth of a tumor comprising administering to an individual in need of treatment:
- i) an anti-tumor antibody, alone or conjugated to a cytotoxic agent, and ii) an anti-idiotypic antibody, wherein the anti-idiotypic antibody is directed to the anti-tumor antibody, wherein the anti-tumor antibody is trastuzumab or trastuzumab conjugated to the cytotoxic agent, and wherein the anti-idiotypic antibody comprises a derivative of SEQ ID NO:2, wherein the sequence of the derivative of SEQ ID NO:2 is selected from SEQ ID NO:2 comprising a mutation of the sequence of SEQ ID NO:2 selected from the group of mutations consisting of T103A, L11M, F29L, V32A, K76R, Y111H, N54D, D56G, N74S, Q13H, S85N, T103S, G10D, S31G, D56V, A97V, D56Y, D56N, S57G, a deletion of E1-M34, T103I, D16A, S17G, S631, Y111N, G9D, T28A, T58A, K87E, Q117L, L18Q, V64A, T69S, and a combination thereof.
Dependencies are inferred from the claim text.