Methods and compositions for diabetes treatment and β-cell regeneration
AssigneeThe Regents of the University of California
InventorSlavica Tudzarova-Trajkovska
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Abstract
Aspects of the present disclosure are directed to methods and compositions for facilitating β-cell regeneration by inhibition of the HIF1α-PFKFB3 pathway. Certain aspects describe methods for treatment and prevention of prediabetes and diabetes, including type 2 diabetes. Also disclosed are methods and compositions for enhancing β-cell regeneration.
Claims14
A method of treating a subject for type 2 diabetes, the method comprising administering an effective amount of a PFKFB3 inhibitor to the subject.
A method of treating a subject for type 2 diabetes, the method comprising:
- (a) determining a subject to have an increased expression level of PFKFB3 in β-cells from the subject relative to an expression level of PFKFB3 in β-cells from a healthy subject who is not suffering from type 2 diabetes;
- and
- (b) administering an effective amount of a PFKFB3 inhibitor to the subject.
A method for stimulating cell death in damaged β-cells expressing PFKFB3, the method comprising providing a PFKFB3 inhibitor to the damaged β-cells.
Dependencies are inferred from the claim text.